First of all we would like to wish all of you a Merry Christmas from @anthropologyglobal family.

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Today we will be discussing some fascinating things about Pardis C. Sabeti, including a bit about her latest research work. Also we would like to wish her a very happy birthday.

She was born on this day in 1975 in Iran. When she was two years older her family fled from Iran to USA before the Iranian Revolution. They took refuge in Florida, USA. She grew up in Orlando. Starting from her school days she started signs of becoming an intellectual identity. Right in high school she managed to receive National Merit Scholarship. Thereafter she went to study Biology in Massachusetts Institute of Technology and even though she was a member of varsity tennis team and a class president she managed to receive a perfect 5.0 average with a major in Biology. Few years later she received her doctorate in evolutionary genetics from the University of Oxford as a Rhodes Scholar. She also graduated  summa cum laude (Meaning with highest honor, awarded to only  top 1-5%  students of the class in North America) from Harvard Medical school with a Doctor of Medicine, being the third women since the University started accepting female students. After completing her studies in medicine, instead of becoming a doctor she went on to pursue a career in research.

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She is also the lead singer and writer  of band  Thousand Days. During her leisure time she loves to play Volley ball and takes it seriously so , during Harvard Summer Volleyball League she turns to an active participant.

Now going towards her research work,during her postdoctoral days in Oxford with fellow Eric Lander at the Broad Institute , she developed a family of statistical tests for positive selection that looks for common genetic variants found on usually long haplotypes.

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Currently she is a professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Diseases at the Harvard School of Public Health. She is the head of the Sabeti lab in Harvard .

Their lab uses three different research foci :

1. They develop analytical and experimental methods to detect and investigate natural selection in the genome of humans and other species.

2. Examine host and viral genetic factors driving resistance to Lassa Fever in West Africa.

3. They also examine signals of natural selection in pathogens, including Lassa virus, Ebola virus, and Plasmodium falciparum malaria to understand how they rapidly evolve, and studying their genetic diversity to guide long term intervention strategies.

Their research team has developed Computational methods like LRH, XP-EHH tests so as to be able to detect genetic variants under positive selection.These methods help them in identifying variants that have recently emerged and spread through population, relying on the breakdown of recombination as a clock for estimating the age of alleles.

They are working in collaboration with Tulane University and USAMRIID and are trying to carry out in-depth genomic analysis and diversity studies elucidating regions of selection and identifying novel strains. If they can generate full-length sequences , it will help them in creating accurate phylogenies for Lassa fever as well as Ebola Viruses.

All in all they are working pretty hard to subside the various types viral and bacterial diseases, creating a much better world. Let us pray for them in this holy day and hope that they receive success in their efforts and endeavors.

Friends don’t you think this lady is such an inspiration. We would like to know , who is your inspiration as well, please comment mentioning your inspiration in the comment box. 

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